{"id":5977,"date":"2024-04-05T07:33:23","date_gmt":"2024-04-05T07:33:23","guid":{"rendered":"https:\/\/staging5.iclickwebdesign.sg\/nscc\/?post_type=portfolio&#038;p=5977"},"modified":"2024-07-11T03:17:37","modified_gmt":"2024-07-11T03:17:37","slug":"advancing-drug-discovery-research-using-nscc-hpc-resources","status":"publish","type":"portfolio","link":"https:\/\/www-7171.nscc.sg\/portfolio\/item\/advancing-drug-discovery-research-using-nscc-hpc-resources\/","title":{"rendered":"Advancing Drug Discovery Research using NSCC HPC resources"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5977\" class=\"elementor elementor-5977\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-75d3820 elementor-section-full_width elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"75d3820\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-305e4c3\" data-id=\"305e4c3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-0209748 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"0209748\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-fc582d9\" data-id=\"fc582d9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8c1776e elementor-widget elementor-widget-itsulu-intro\" data-id=\"8c1776e\" data-element_type=\"widget\" data-widget_type=\"itsulu-intro.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t<!-- banner -->\n\t\t<div class=\"mil-banner-sm\">\n\t\t\t\t\t\t<div class=\"mil-banner-content\">\n\t\t\t\t\t\t\t\t<div class=\"mil-breadcrumbs mil-mb-30 mil-light\">\n\t\t\t\t\t<ul><li><a href=\"https:\/\/www-7171.nscc.sg\" title=\"NSCC\"><span>NSCC Singapore<\/span><\/a><\/li><li class=\"current\"><span><\/span><\/li><\/ul>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<h1 class=\"mil-h2 mil-uppercase mil-light\">\n\t\t\t\t\t<span >\n\t\t\t\t\t\tAdvancing Drug Discovery Research using NSCC HPC resources\t\t\t\t\t<\/span>\n\t\t\t\t<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mil-suptitle mil-accent mil-light\">\n\t\t\t\t\t<span >\n\t\t\t\t\t\tResearchers from Nanyang Technological University (NTU) are applying variational graph encoders as an effective generalist algorithm in computer-aided drug design (CADD).\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t<!-- banner end -->\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-daf0b91 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"daf0b91\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c4a8aa7\" data-id=\"c4a8aa7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-61161cf elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"61161cf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6d913d9\" data-id=\"6d913d9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c0b8bba elementor-widget elementor-widget-image\" data-id=\"c0b8bba\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"478\" src=\"https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-101857-768x478-1.png\" class=\"attachment-large size-large wp-image-6014\" alt=\"\" srcset=\"https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-101857-768x478-1.png 768w, https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-101857-768x478-1-300x187.png 300w, https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-101857-768x478-1-200x124.png 200w, https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-101857-768x478-1-400x249.png 400w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25fcf2d elementor-widget elementor-widget-text-editor\" data-id=\"25fcf2d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>\u00a0<\/p><p>Selecting ideal drug molecules from a chemical space of over 1063 molecules is extremely challenging, compounded by high failure rates in clinical research, which make the time and the financial costs of drug development daunting. Although CADD has significantly reduced these costs, there are still many issues to be resolved in practical research.<\/p><p>\u00a0<\/p><p>Currently, many models specialize in predicting a single property of a chemical compound, such as solubility. Existing CADD techniques focus on discovering and optimizing small molecule drugs, but predictions and optimizations of pharmacological and toxicological properties remain unsatisfactory.<\/p><p>\u00a0<\/p><p>Therefore, researchers from NTU have embarked on this work to find a single model capable of predicting multiple properties simultaneously. The model will be able to expedite the drug discovery process.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f94ecb elementor-widget elementor-widget-itsulu-divider\" data-id=\"5f94ecb\" data-element_type=\"widget\" data-widget_type=\"itsulu-divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t<div class=\"mil-divider\"><\/div>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e1f7764 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"e1f7764\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c2d9e62\" data-id=\"c2d9e62\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74c0e8a elementor-widget elementor-widget-accordion\" data-id=\"74c0e8a\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-accordion{text-align:start}.elementor-accordion .elementor-accordion-item{border:1px solid #d5d8dc}.elementor-accordion .elementor-accordion-item+.elementor-accordion-item{border-top:none}.elementor-accordion .elementor-tab-title{margin:0;padding:15px 20px;font-weight:700;line-height:1;cursor:pointer;outline:none}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{display:inline-block;width:1.5em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon svg{width:1em;height:1em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-right{float:right;text-align:right}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-left{float:left;text-align:left}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-closed{display:block}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-opened,.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-closed{display:none}.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-opened{display:block}.elementor-accordion .elementor-tab-content{display:none;padding:15px 20px;border-top:1px solid #d5d8dc}@media (max-width:767px){.elementor-accordion .elementor-tab-title{padding:12px 15px}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{width:1.2em}.elementor-accordion .elementor-tab-content{padding:7px 15px}}.e-con-inner>.elementor-widget-accordion,.e-con>.elementor-widget-accordion{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1221\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1221\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg class=\"e-font-icon-svg e-fas-chevron-up\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">The Research<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1221\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1221\"><p>Molecules and compounds used in our daily drugs vary in shapes and sizes. Currently, there are an estimated 1063 unique compounds that have the potential to be used as pharmaceutical drugs. However, these molecules are discrete in nature and cannot be easily represented mathematically.<\/p><p>\u00a0<\/p><p>In this research, the researchers employed a variational graph encoder to convert individual molecules into a continuous numerical space. Consequently, each molecule can now be represented using 64 numbers.<\/p><p>\u00a0<\/p><p>Using these 64 numbers, they demonstrated the capability to predict various compound properties, including absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles.<\/p><p>\u00a0<\/p><p>This research specifically showcased that building smaller models based on these 64 numbers generated competent models that were comparable to or on par with state-of-the-art approaches, hence it was tagged as a \u201cgeneralist\u201d model. Additionally, the researchers discovered that the 64 numbers output from the model can be directly explored using other AI methods, enabling the effective specification of desired drug properties and automatic exploration for molecules that meet the criteria through the use of AI.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1222\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1222\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg class=\"e-font-icon-svg e-fas-chevron-up\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">The Technology<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1222\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1222\"><p><strong><em>Molecule clustering from the ZINC database:<\/em><\/strong>\u00a0Approximately 690 million molecules sourced from the ZINC database were split on their tranches and used for downstream training of the variational graph encoder.<\/p><p>\u00a0<\/p><p><strong><em>Latent space surrogate model:<\/em><\/strong>\u00a0Training of a specific machine learning model to predict the binding affinity of small molecules to a specific protein.<\/p><p>\u00a0<\/p><p><em><strong>HPC resources:<\/strong>\u00a0<\/em>The project was allocated 500,000 CPU and 500,000 GPU hours from NSCC Singapore. These resources facilitated large-scale virtual screening, computational tasks and scoring of the test targets.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1223\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1223\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg class=\"e-font-icon-svg e-fas-chevron-up\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">The Impact<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1223\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1223\"><p><em><strong>Increased Speed:\u00a0<\/strong><\/em>\u00a0The surrogate models developed by the researchers using latent space information, not only excel in predicting properties like ADMET but also notably accelerate virtual screening in ligand-based drug design.<\/p><p>\u00a0<\/p><p><strong><em>Increased Accuracy:<\/em><\/strong>\u00a0Employing the surrogate support vector machine model alongside five scoring functions, the researchers predicted compound affinity for five target proteins. The results demonstrated comparable accuracy in ranking ability to specialized scoring functions, while reducing computational time by 1-2 orders of magnitude. This significantly minimizes the computational resources required to process the evaluations.<\/p><p>\u00a0<\/p><p><strong><em>Prospects:\u00a0<\/em><\/strong>The NTU team will be working towards applying this innovative methodology to conduct virtual screenings across extensive datasets within the molecule library.<\/p><p>\u00a0<\/p><p><img decoding=\"async\" class=\"aligncenter wp-image-6022 size-full\" src=\"https:\/\/ncss.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-102011-768x277-1.png\" alt=\"\" width=\"768\" height=\"277\" srcset=\"https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-102011-768x277-1.png 768w, https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-102011-768x277-1-300x108.png 300w, https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-102011-768x277-1-200x72.png 200w, https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Screenshot-2024-03-28-102011-768x277-1-400x144.png 400w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-adc66de elementor-widget elementor-widget-text-editor\" data-id=\"adc66de\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>To find out more about how NSCC\u2019s HPC resources can help you, please contact\u00a0<a class=\"mil-accent\" href=\"mailto:e-news@nscc.sg\">e-news@nscc.sg<\/a>.<\/p><p>\u00a0<\/p><section class=\"case-studies-info\"><p style=\"text-align: left;\">NSCC NewsBytes <a class=\"mil-accent\" href=\"https:\/\/www.nscc.sg\/wp-content\/uploads\/2024\/03\/Mar-Newsbytes_Final.pdf\">March 2024<\/a><\/p><\/section>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2228a96 elementor-widget elementor-widget-itsulu-button\" data-id=\"2228a96\" data-element_type=\"widget\" data-widget_type=\"itsulu-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t\t\t<!-- Button -->\n\t\t<a class=\"mil-link\" href=\"\/nscc\/case-studies\/\">\n\t\t\t\t\t\t<span >\n\t\t\t\tBack To Case Studies\t\t\t<\/span>\n\t\t\t<i class=\"fas fa-arrow-right\"><\/i>\t\t\t    \t<\/a>\n\t\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e7f64ca elementor-widget elementor-widget-spacer\" data-id=\"e7f64ca\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c9c0f27 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"c9c0f27\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7fd8922\" data-id=\"7fd8922\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-dd6ce82 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"dd6ce82\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-2e9c877\" data-id=\"2e9c877\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d543c4d elementor-widget elementor-widget-heading\" data-id=\"d543c4d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\"><span class=\"mil-accent\">Other<\/span> Case Studies<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0e21bb elementor-widget elementor-widget-itsulu-portfolio-carousel\" data-id=\"f0e21bb\" data-element_type=\"widget\" data-widget_type=\"itsulu-portfolio-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t\t\t<div class=\"swiper-container mil-events-slider\" data-autoplay=\"6000\">\n\t\t\t<div class=\"mil-adaptive-right\">\n\t\t\t\t<div class=\"mil-slider-nav\">\n\t\t\t\t\t<div class=\"mil-slider-btn-prev mil-events-prev\"><i class=\"fas fa-arrow-left\"><\/i><span class=\"mil-h6\">Prev<\/span><\/div>\n\t\t\t\t\t<div class=\"mil-slider-btn-next mil-events-next\"><span class=\"mil-h6\">Next<\/span><i class=\"fas fa-arrow-right\"><\/i><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"swiper-wrapper\">\n\t\t\t\t\t\t\t\t\t\n\n<div class=\"swiper-slide\">\n\t<a href=\"https:\/\/www-7171.nscc.sg\/portfolio\/item\/studying-the-potential-effect-of-storm-surges-and-tsunamis-on-coastal-regions-in-the-south-china-sea\/\" class=\"mil-card-2\">\n\t\t\t\t<div class=\"mil-cover-frame\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Untitled-design-68.png\" alt=\"Studying the potential effect of storm surges and tsunamis on coastal regions in the South China Sea\" \/>\n\t\t<\/div>\n\t\t\t\t<div class=\"mil-description\">\n\t\t\t<div class=\"mil-card-title\">\n\t\t\t\t\t\t\t\t<div class=\"mil-h6 mil-accent mil-mb-10\">\n\t\t\t\t\t<span>Urban Solutions and Sustainability<\/span>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mil-h4 mil-mb-15\">\n\t\t\t\t\tStudying the potential effect of storm surges and tsunamis on coastal regions in the South China Sea\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"mil-card-text\">\n\t\t\t\t<div>\n\t\t\t\t\t<p>A research team from NUS is harnessing high performance computing to quantify the uncertainty of earthquake characteristics and tropical cyclone storm surges to estimate its&#8230;<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t<\/a>\n<\/div>\n\n\n<div class=\"swiper-slide\">\n\t<a href=\"https:\/\/www-7171.nscc.sg\/portfolio\/item\/enhancing-weather-prediction-in-singapore-leveraging-climate-model-simulations-for-precision\/\" class=\"mil-card-2\">\n\t\t\t\t<div class=\"mil-cover-frame\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/weather-prediction.png\" alt=\"Enhancing Weather Prediction in Singapore: Leveraging Climate Model Simulations for Precision\" \/>\n\t\t<\/div>\n\t\t\t\t<div class=\"mil-description\">\n\t\t\t<div class=\"mil-card-title\">\n\t\t\t\t\t\t\t\t<div class=\"mil-h6 mil-accent mil-mb-10\">\n\t\t\t\t\t<span>Urban Solutions and Sustainability<\/span>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mil-h4 mil-mb-15\">\n\t\t\t\t\tEnhancing Weather Prediction in Singapore: Leveraging Climate Model Simulations for Precision\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"mil-card-text\">\n\t\t\t\t<div>\n\t\t\t\t\t<p>Researchers from NUS Tropical Marine Science Institute are leveraging supercomputing to fine-tune Weather Research and Forecasting (WRF) Model and downscale hundreds of years of&#8230;<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t<\/a>\n<\/div>\n\n\n<div class=\"swiper-slide\">\n\t<a href=\"https:\/\/www-7171.nscc.sg\/portfolio\/item\/taking-a-stratified-approach-to-the-prevention-of-type-2-diabetes-in-the-asian-population\/\" class=\"mil-card-2\">\n\t\t\t\t<div class=\"mil-cover-frame\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/08\/Untitled-design-4-1200x675.jpg\" alt=\"Taking a stratified approach to the prevention of Type 2 diabetes in the Asian population\" \/>\n\t\t<\/div>\n\t\t\t\t<div class=\"mil-description\">\n\t\t\t<div class=\"mil-card-title\">\n\t\t\t\t\t\t\t\t<div class=\"mil-h6 mil-accent mil-mb-10\">\n\t\t\t\t\t<span>Health and Biomedical Sciences<\/span>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mil-h4 mil-mb-15\">\n\t\t\t\t\tTaking a stratified approach to the prevention of Type 2 diabetes in the Asian population\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"mil-card-text\">\n\t\t\t\t<div>\n\t\t\t\t\t<p><strong><em>Researchers from Nanyang Technological University (NTU) and their collaborators are investigating the molecular regulatory disturbances underlying development of Type 2 diabetes amongst Asian populations.<\/em><\/strong><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t<\/a>\n<\/div>\n\n\n<div class=\"swiper-slide\">\n\t<a href=\"https:\/\/www-7171.nscc.sg\/portfolio\/item\/supercomputers-aid-in-research-to-control-ozone-pollution\/\" class=\"mil-card-2\">\n\t\t\t\t<div class=\"mil-cover-frame\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Untitled-design-23.png\" alt=\"Supercomputers aid in research to control ozone pollution\" \/>\n\t\t<\/div>\n\t\t\t\t<div class=\"mil-description\">\n\t\t\t<div class=\"mil-card-title\">\n\t\t\t\t\t\t\t\t<div class=\"mil-h6 mil-accent mil-mb-10\">\n\t\t\t\t\t<span>Urban Solutions and Sustainability<\/span>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mil-h4 mil-mb-15\">\n\t\t\t\t\tSupercomputers aid in research to control ozone pollution\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"mil-card-text\">\n\t\t\t\t<div>\n\t\t\t\t\t<p>Researchers from NTU leverage high-performance computing resources to better understand the effects of ozone pollution and develop tools to control emissions in Southeast Asia&#8230;.<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t<\/a>\n<\/div>\n\n\n<div class=\"swiper-slide\">\n\t<a href=\"https:\/\/www-7171.nscc.sg\/portfolio\/item\/harnessing-supercomputers-to-correct-quantum-errors\/\" class=\"mil-card-2\">\n\t\t\t\t<div class=\"mil-cover-frame\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Credit-NTU-7.png\" alt=\"Harnessing supercomputers to correct quantum errors\" \/>\n\t\t<\/div>\n\t\t\t\t<div class=\"mil-description\">\n\t\t\t<div class=\"mil-card-title\">\n\t\t\t\t\t\t\t\t<div class=\"mil-h6 mil-accent mil-mb-10\">\n\t\t\t\t\t<span>Advanced Manufacturing and Engineering<\/span>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mil-h4 mil-mb-15\">\n\t\t\t\t\tHarnessing supercomputers to correct quantum errors\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"mil-card-text\">\n\t\t\t\t<div>\n\t\t\t\t\t<p>Researchers at SUTD and Yale-NUS are tapping HPC resources to study the occurrence of errors in quantum computations and devise models to better correct errors. A quantum&#8230;<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t<\/a>\n<\/div>\n\n\n<div class=\"swiper-slide\">\n\t<a href=\"https:\/\/www-7171.nscc.sg\/portfolio\/item\/simulating-combustion-processes-in-marine-engines-to-reduce-carbon-footprint\/\" class=\"mil-card-2\">\n\t\t\t\t<div class=\"mil-cover-frame\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/www-7171.nscc.sg\/wp-content\/uploads\/2024\/04\/Simulating-Combustion-Processes-In-Marine-Engines-To-Reduce-Carbon-Footprint.png\" alt=\"Simulating combustion processes in marine engines to reduce carbon footprint\" \/>\n\t\t<\/div>\n\t\t\t\t<div class=\"mil-description\">\n\t\t\t<div class=\"mil-card-title\">\n\t\t\t\t\t\t\t\t<div class=\"mil-h6 mil-accent mil-mb-10\">\n\t\t\t\t\t<span>Advanced Manufacturing and Engineering<\/span>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"mil-h4 mil-mb-15\">\n\t\t\t\t\tSimulating combustion processes in marine engines to reduce carbon footprint\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"mil-card-text\">\n\t\t\t\t<div>\n\t\t\t\t\t<p>Using supercomputers to study the various aspects of fuel utilisation in shipping helps combat pollution The drive for enhanced energy efficiency, lower pollution and&#8230;<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t<\/a>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"featured_media":11954,"menu_order":0,"template":"template-elementor-default.php","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"portfolio_categories":[21],"class_list":["post-5977","portfolio","type-portfolio","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www-7171.nscc.sg\/wp-json\/wp\/v2\/portfolio\/5977"}],"collection":[{"href":"https:\/\/www-7171.nscc.sg\/wp-json\/wp\/v2\/portfolio"}],"about":[{"href":"https:\/\/www-7171.nscc.sg\/wp-json\/wp\/v2\/types\/portfolio"}],"version-history":[{"count":36,"href":"https:\/\/www-7171.nscc.sg\/wp-json\/wp\/v2\/portfolio\/5977\/revisions"}],"predecessor-version":[{"id":14154,"href":"https:\/\/www-7171.nscc.sg\/wp-json\/wp\/v2\/portfolio\/5977\/revisions\/14154"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www-7171.nscc.sg\/wp-json\/wp\/v2\/media\/11954"}],"wp:attachment":[{"href":"https:\/\/www-7171.nscc.sg\/wp-json\/wp\/v2\/media?parent=5977"}],"wp:term":[{"taxonomy":"portfolio_categories","embeddable":true,"href":"https:\/\/www-7171.nscc.sg\/wp-json\/wp\/v2\/portfolio_categories?post=5977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}